| 二[4-羟基-5,6-二氢-6-烷基(芳基)-2H-吡喃-2-酮-3-]烃的合成及生物活性的研究 |
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| 引用本文： | 李玉新,王有名,王素华,杨小平,李正名.二[4-羟基-5,6-二氢-6-烷基(芳基)-2H-吡喃-2-酮-3-]烃的合成及生物活性的研究[J].高等学校化学学报,2004,25(2):281-283. |
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| 作者姓名： | 李玉新 王有名 王素华 杨小平 李正名 |
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| 作者单位： | 1. 元素有机化学重点实验室, 南开大学元素有机化学研究所, 天津 300071;
2. 湘潭师范学院化学系, 湘潭 411201 |
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| 基金项目： | 国家自然科学基金 (批准号 :2 983 2 0 5 0 )资助 |
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| 摘 要： | 采用5,6-二氢-6-烷基(芳基)-2H-吡喃-2,4-二酮和醛进行缩合反应,合成了二4-羟基-5,6-二氢-6-烷基(芳基)-2H-吡喃-2-酮-3-]烃.其结构经1HNMR和元素分析证实.对反应条件(反应温度、反应时间)进行了探讨.生物活性初步测定表明,该类化合物具有一定的杀菌和抗烟草花叶病毒的活性.
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| 关 键 词： | 缩合反应 反应条件 杀菌活性 抗烟草花叶病毒活性 |
| 文章编号： | 0251-0790(2004)02-0281-03 |
| 收稿时间： | 2002-12-27 |
Synthesis and Biological Activities of Bis[4-hydroxy-5,6-dihydro-6-alkyl(aryl)-2H-pyran-2-one-3-] methane |
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| LI Yu-Xin ,WANG You-Ming ,WANG Su-Hua ,YANG Xiao-Ping ,LI Zheng-Ming.Synthesis and Biological Activities of Bis[4-hydroxy-5,6-dihydro-6-alkyl(aryl)-2H-pyran-2-one-3-] methane[J].Chemical Research In Chinese Universities,2004,25(2):281-283. |
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| Authors: | LI Yu-Xin WANG You-Ming WANG Su-Hua YANG Xiao-Ping LI Zheng-Ming |
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| Institution: | 1. State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China;
2. Department of Chemistry, Xiangtan Normal University, Xiangtan 411201, China |
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| Abstract: | We attempted to build a carbon-carbon single bond in 3 position of 5,6-dihydro-6-alkyl(aryl)-2H-pyran-2,4-diones by Mannich reaction, but failed to gain the title compounds and the unexpected products were obtained. 5,6-Dihydro-6-alkyl(aryl)-2H-pyran-2,4-diones with aldehydes and a series of bis4-hydroxy-5,6-dihydro-6-alkyl(aryl)-2H-pyran-2-one-3-] methanes were obtained. Their structures were confirmed by 1H NMR spectra and elemental analyses. In order to discuss this new condensation reaction, its reaction conditions were discussed. Compounds 3 were tested in vitro against many fungi such as P. Zeae, C. Arachidicala, P. Piricola, A. Solani, B. Cinerae, S. Sclerotiorum and H. Oryzae. The bioassay results show that they have some fungicidal tobacco virucidal activities. |
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| Keywords: | Condensation reaction Reaction condition Fungicidal activity Tobacco virucidal activity |
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