Copper complexes as chemical nucleases |
| |
Authors: | Akhil R Chakravarty Pattubala A N Anreddy Bidyut K Santra and Anitha M Thomas |
| |
Institution: | (1) Department of Inorganic and Physical Chemistry, Indian Institute of Science, 560 012 Bangalore, India |
| |
Abstract: | Redox active mononuclear and binuclear copper(II) complexes have been prepared and structurally characterized. The complexes have planar N-donor heterocyclic bases like 1,10-phenanthroline
(phen), dipyridoquinoxaline (dpq) and dipyridophenazine (dppz) ligands that are suitable for intercalation to B-DNA. Complexes
studied for nuclease activity have the formulations Cu(dpq)2(H2O)] (ClO4)2.H2O (1), CuL(H2O)2(μ-ox)](ClO4)2 (L = bpy,2; phen,3; dpq,4; and dppz,5) and Cu(L)(salgly)] (L = bpy,6; phen,7; dpq,8; and dppz,9), where salgly is a tridentate Schiff base obtained from the condensation of glycine and salicylaldehyde. The dpq complexes
are efficient DNA binding and cleavage active species. The dppz complexes show good binding ability but poor nuclease activity.
The cleavage activity of thebis-dpq complex is significantly higher than thebis-phen complex of copper(II). The nuclease activity is found to be dependent on the intercalating nature of the complex and
on the redox potential of the copper(II)/copper(I) couple. The ancillary ligand plays a significant role in binding and cleavage
activity. |
| |
Keywords: | Copper(II) complexes nuclease activity catalytic properties DNA binding |
本文献已被 SpringerLink 等数据库收录! |
|