Synthesis of novel glycosyl-1,2,3-1H-triazolyl methyl quinazolin-4(3H)-ones and their effect on GLUT4 translocation |
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| Authors: | K Kumar G Ramakrishna Ravi Kumar Thakur Venkata Reddy Pasam Jyotsana Pandey Rohit Mahar Sanjeev K Shukla Akhilesh K Tamrakar Rama Pati Tripathi |
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| Institution: | 1. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India;2. Biochemistry Division, CSIR-Central Drug Research Institute, Lucknow 226031, India;3. Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow 226031, India;4. Academy of Scientific & Innovative Research (AcSIR), New Delhi, India |
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| Abstract: | Cu(OTf)2 catalyzed synthesis of propargylated 2,3-dihydroquinazolin-4(1H)-ones has been accomplished from 2-amino-N-propargyl benzamides and aromatic aldehydes under MW irradiation. Next, a series of novel glycosyl triazolyl methyl quinazolin-4(3H)-ones have been synthesized by CuAAC reaction of propargylated 2,3-dihydroquinazolin-4(1H)-ones with glycosyl azides followed by iodine mediated oxidation. In this series, six compounds showed promising to significant GLUT4 translocation activity comparable to rosiglitazone. |
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| Keywords: | Copper(II) triflate GLUT4 translocation activity |
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