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One step synthesis of indirubins by reductive coupling of isatins with KBH4 |
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| Authors: | Cuiling Wang Jiaxu Yan Mo Du Joseph A. Burlison Chi Li Yanni Sun Danqing Zhao Jianli Liu |
| Affiliation: | 1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi''an 710069, China;2. James Graham Brown Cancer Center, Department of Medicine, University of Louisville, Louisville, KY 40202, United States |
| Abstract: | One step synthesis of the natural product indirubin by reductive coupling of isatin with KBH4 is described and a possible mechanism for the reaction is proposed. Eleven indirubin derivatives were obtained easily from the corresponding substituted isatin. |
| Keywords: | Indirubin Synthesis Isatin Reductive coupling |
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