A new steroid with unique rearranged seven-membered B ring isolated from roots of Asparagus filicinus |
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| Authors: | Jia-Peng Wang Le Cai Feng-Yun Chen Yuan-Yuan Li Yuan-Ya Li Ping Luo Zhong-Tao Ding |
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| Institution: | Key Laboratory of Functional Molecules Analysis and Biotransformation, Yunnan Provincial Department of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China |
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| Abstract: | A novel skeleton steroid aspafilisine (1), which has a unique rearranged seven-membered B ring formed by the C(7)–C(14) linkage were isolated from the roots of Asparagus filicinus. A novel hemiketal derivative (1a) was synthesized to identify the structure of 1. The structures of 1 and 1a were elucidated by 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of 1 was assigned on the basis of ROESY spectrum, comparison with literature and computational methods. A plausible biosynthetic pathway of 1 was also proposed. |
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| Keywords: | Steroid Seven-membered B ring Aspafilisine |
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