New insights into the seleniranium ion promoted cyclization of prenyl and propenylbenzene aryl ethers |
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| Authors: | Serena Fiorito Francesco Epifano Francesca Preziuso Vito Alessandro Taddeo Claudio Santi Salvatore Genovese |
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| Affiliation: | 1. Dipartimento di Farmacia, Università “G. D''Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy;2. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 06132 Perugia, Italy |
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| Abstract: | ![]()
The chromane core is widely represented in nature being part of a wide array of secondary metabolites of plant, fungal, and bacterial origin. In this paper an improved method for the chemical synthesis of differently substituted chromanes is described. Substituted 2H-1-benzopyrans have been synthesized in good to excellent yields (52–81%) by treatment of 3,3-dimethylallyl and propenylbenzene ethers of differently substituted phenols with phenylselenyl chloride. |
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| Keywords: | Carbocyclizations Chromanes Natural products Organoselenium compounds Oxyprenylated secondary metabolites |
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