Saxifraganoids A and B,two novel cucurbitane triterpenoid glycosides from Saxifraga umbellulata var. pectinata |
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| Authors: | Wei Jiang Yao Fei Xiao-Lang Du Ze-Jing Mu Bo Li Shou-Wen Zhang Guo-Yue Zhong |
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| Institution: | 1. Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, PR China;2. Jiangxi Synergistic Innovation Center of Modern Technology and Industrial Development of Traditional Ethnic Medicines, Nanchang, Jiangxi 330004, PR China;3. Department of Traditional Chinese Medicine, Chongqing Medical University, Chongqing 400016, PR China |
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| Abstract: | Two novel cucurbitane triterpenoid glycosides, named saxifraganoids A (1) and B (2), were isolated from Saxifraga umbellulata var. pectinata. Their structures including absolute configurations were elucidated based on the analysis of spectroscopic data (1D, 2D NMR and HRMS), and single-crystal X-ray diffraction. Compound 1 represents the first example of cucurbitane triterpenoid with a Δ17(20), and compound 2 contained an unusual N-acetylglucosamine at C-16. The protective effects against liver injury induced by carbon tetrachloride (CCl4) in the human embryonic-liver L-02 cells of these two compounds were evaluated. |
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| Keywords: | Cucurbitane triterpenoid Saxifraganoid Liver injury |
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