| PPEGMEA-g-PDEAEMA全亲水接枝共聚物的合成及其包埋甲氨喋呤体外控释的研究 |
| |
| 引用本文： | 黄晓炜,顾丽娜,陆国林,黄啸,张亚琴,黄晓宇. PPEGMEA-g-PDEAEMA全亲水接枝共聚物的合成及其包埋甲氨喋呤体外控释的研究[J]. 化学学报, 2009, 67(12): 1363-1369 |
| |
| 作者姓名： | 黄晓炜 顾丽娜 陆国林 黄啸 张亚琴 黄晓宇 |
| |
| 作者单位： | 复旦大学附属肿瘤医院妇科,复旦大学上海医学院肿瘤学系,上海,200032;中国科学院上海有机化学研究所,上海,200032 |
| |
| 基金项目： | 上海市纳米专项,上海市青年科技启明星计划,中国科学院青年人才领域前沿项目和卫生部(竹世)川医学奖学金同学会科研启动基金 |
| |
| 摘 要： | 以聚乙二醇丙烯酸酯(PEGMEA)为起始原料, 将原子转移自由基聚合(ATRP)技术和从主干接枝(grafting-from)策略相结合, 合成了结构规整的聚甲基醚聚乙二醇丙烯酸酯-g-聚(N,N’-二乙基胺乙基甲基丙烯酸酯) (PPEGMEA-g- PDEAEMA)接枝共聚物. 这种接枝共聚物通过静电作用形成胶束包埋甲氨喋呤(MTX), 得到具有98.7%高包封率的药物载体, 体外药物释放得到很好的控制.
|
| 关 键 词： | 全亲水接枝共聚物 胶束 药物控释 |
| 收稿时间： | 2009-02-16 |
| 修稿时间： | 2009-03-17 |
Synthesis of PPEGMEA-g-PDEAEMA Double Hydrophilic Graft Copolymer and Studies on Controlled Drug Release in vitro of Loaded Methotrexate |
| |
| Huang Xiaowei,Gu Lina,Lu Guolin,Huang Xiao,Zhang Yaqin,Huang Xiaoyu. Synthesis of PPEGMEA-g-PDEAEMA Double Hydrophilic Graft Copolymer and Studies on Controlled Drug Release in vitro of Loaded Methotrexate[J]. Acta Chimica Sinica, 2009, 67(12): 1363-1369 |
| |
| Authors: | Huang Xiaowei Gu Lina Lu Guolin Huang Xiao Zhang Yaqin Huang Xiaoyu |
| |
| Affiliation: | (a Department of Gynecology, Cancer Hospital, Fudan University; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032) (b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032) |
| |
| Abstract: | A well-defined poly[poly(ethylene glycol) methyl ether acrylate]-g-poly[(N,N’-diethylamino)- ethyl methacrylate] (PPEGMEA-g-PDEAEMA) graft copolymer was synthesized by the combination of atom radical transfer polymerization (ATRP) and the grafting-from strategy using poly(ethylene glycol) methyl ether acrylate (PEGMEA) as starting material. PPEGMEA-g-PDEAEMA-based micelles formed by electrostatic complexes were employed to load methotrexate (MTX) with a high drug loading efficiency of 98.7% and the drug release in vitro was well controlled. |
| |
| Keywords: | double hydrophilic graft copolymer micelle drug release |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《化学学报》浏览原始摘要信息 |
|
点击此处可从《化学学报》下载全文 |
|
