| Studies on Hepatocyte-Targeting Magnetic Resonance Imaging Macromolecular Contrast Media |
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| 作者姓名： | FU Yan jun and ZHUO Ren xi ** |
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| 作者单位： | Department of Chemistry，Wuhan University，Laboratory of Biomedical Polymer Materials of the State Education Commission of China，Wuhan，430072 |
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| 摘 要： | ＳｔｕｄｉｅｓｏｎＨｅｐａｔｏｃｙｔｅ┐ＴａｒｇｅｔｉｎｇＭａｇｎｅｔｉｃＲｅｓｏｎａｎｃｅＩｍａｇｉｎｇＭａｃｒｏｍｏｌｅｃｕｌａｒＣｏｎｔｒａｓｔＭｅｄｉａ＊ＦＵＹａｎ－ｊｕｎａｎｄＺＨＵＯＲｅｎ－ｘｉ＊＊（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔ...
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Studies on Hepatocyte Targeting Magnetic Resonance Imaging Macromolecular Contrast Media |
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| FU Yan jun and ZHUO Ren xi,**.Studies on Hepatocyte-Targeting Magnetic Resonance Imaging Macromolecular Contrast Media[J].Chemical Research in Chinese University,1997(4). |
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| Authors: | FU Yan jun and ZHUO Ren xi |
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| Institution: | FU Yan jun and ZHUO Ren xi ** |
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| Abstract: | DTPA was covalently conjugated to the copolymer of L lysine and L tyrosine, then transchelated with Gd EDTA,the resultant polymer chelates were further reacted with 6 O bromoacetyl D galactose or methyl lactobionyloxyacetate to give PLT(Gd DTPA) with galactose moiety as liver targeting group.These macromolecular MRI contrast agents were characterized by means of FT IR, ICP AES, elementary analyses and UV Vis spectrophotometry. Their in vitro relaxivity and liver targeting property in mice were also investigated. |
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| Keywords: | MRI macromolecular contrast media(MMCM) Polylysine Hepatocyte targeting Relaxivity Biodistribution |
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