Promotion Mechanism of H2O for Stereoselectivity in Pd(II)-catalyzed C-H Arylation of Diarylphosphinamides with Arylboronic Acids |
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| Authors: | CAI Yanchun JIAO Long QIU Xuepeng DU Zhijun |
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| Institution: | Polymer Composites Engineering Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China |
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| Abstract: | On the basis of a series of control experiments and nuclear magnetic resonance analyses, it is discovered that Boc-protected amino acid ligand coordinated to Pd center is partly replaced by N,N-dimethylformamide, and H2O can inhibit coordination of N,N-dimethylformamide to Pd center. The novel action mechanism perfectly explains H2O promotion for stereoselectivity in Pd(II)-catalyzed C-H arylation of diarylphosphinamides with arylboronic acids. |
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| Keywords: | C-H activation Stereoselectivity Water Ligand exchange |
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