|
|||||
|
|
Lipase catalysis in the preparation of 3-(1-amino-3-butenyl)pyridine enantiomers |
|
| Authors: | Ari Hietanen Tiina Saloranta Reko Leino Liisa T. Kanerva |
| Affiliation: | 1. Institute of Biomedicine/Department of Pharmacology, Drug Development and Therapeutics/Laboratory of Synthetic Drug Chemistry and Department of Chemistry, University of Turku, FIN-20014 Turku, Finland;2. Laboratory of Organic Chemistry, Åbo Akademi University, FI-20500 Åbo, Finland |
| Abstract: | The kinetic resolution of 1-(3-pyridyl)buten-3-ylamine with activated and non-activated acyl donors and Burkholderia cepacia lipase (lipase PS-D) under dry conditions has been studied. The N-acylation in isopropyl acetate (E >100) and the acidic hydrolysis of the (R)-amide produced gave the corresponding enantiomerically enriched amines. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |