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New Steroidal Saponins Isolated from the Rhizomes of Paris mairei
Authors:Yang Liu  Pengcheng Qiu  Minchang Wang  Yunyang Lu  Hao He  Haifeng Tang  Bang-Le Zhang
Abstract:The genus Paris is an excellent source of steroidal saponins that exhibit various bioactivities. Paris mairei is a unique species and has been widely used as folk medicine in Southwest China for a long time. With the help of chemical methods and modern spectra analysis, five new steroidal saponins, pamaiosides A–E (1–5), along with five known steroidal saponins 6–10, were isolated from the rhizomes of Paris mairei. The cytotoxicity of all the new saponins was evaluated against human pancreatic adenocarcinoma PANC-1 and BxPC3 cell lines.
Keywords:Paris mairei  steroidal saponins  spirostane saponin  15-oxo-18-nor-spirost  cytotoxicity
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