Heteroareno-annelated estranes by triene cyclization |
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| Authors: | Masataka Watanabe Taisuke Matsumoto Shuntaro Mataka Thies Thiemann |
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| Institution: | (1) Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga-shi 816-8580, Japan;(2) Institute of Materials Chemistry and Engineering, Kyushu University, Kasuga-shi 816-8580, Japan |
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| Abstract: | 17-Thienyl-and 17-benzob]thienyl-3-hydroxyestra-1,3,5(10),16-tetraenes were synthesized by either sequential or one-pot Suzuki cross-coupling and
Wittig olefination reactions. At 160 °C, heteroaryl substituted steroids were observed to undergo thermal intramolecular cyclization
to produce E-ring heteroareno-annelated estranes. |
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| Keywords: | Steroids annelation cyclization trienes |
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