|
|||||
|
|
Cubane derivatives |
|
| Authors: | L T Eremenko L B Romanova M E Ivanova V S Malygina L S Barinova G V Lagodzinskaya V P Lodygina I L Eremenko G G Aleksandrov |
| Institution: | 1. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation 2. N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky prosp., 119991, Moscow, Russian Federation |
| Abstract: | New substituted cubane-1,4-dicarboxamides and 4-bromocubanecarboxamides containing the nitroxyl group and amino acid fragments along with the cubane skeleton were synthesized. The cardiac pharmacological activity (both the effect on aorta relaxation and the calcium channel blocking activity) of most of nitroxyalkyl derivatives is equal to or higher than that of N-(2-nitroxyethyl)nicotinamide (nicorandil). |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |