Notiz zur Darstellung von 4-Hydroxy-6-methyl-5,6-dihydro-2H-pyran-2-on |
| |
Authors: | Johannes Häusler |
| |
Affiliation: | (1) Institut für Organische Chemie, Universität Wien, A-1090 Wien, Österreich |
| |
Abstract: | Meldrum's acid (2) is acylated by diketen affording the acylMeldrum's acid3. In aqueous bicarbonate its 3-oxogroup is selectively reduced by sodium tetrahydroborate giving the alcohol4, which readily undergoes cyclization in refluxing dioxane leading to the title pyrone7. Under identical conditions3 produces the pyrone6 with the pyrone carboxylic acid5 as intermediate. |
| |
Keywords: | Acyl Meldrum's acid Ring closure Selective reduction |
本文献已被 SpringerLink 等数据库收录! |