| 聚酯酸酐的合成及其药物释放性能研究 |
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| 引用本文： | 傅杰,卓仁禧,范昌烈.聚酯酸酐的合成及其药物释放性能研究[J].高等学校化学学报,1998,19(5):813-816. |
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| 作者姓名： | 傅杰 卓仁禧 范昌烈 |
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| 作者单位： | 武汉大学化学系, 国家教育委员会生物医用高分子材料开放实验室, 武汉, 430072 |
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| 摘 要： | 将对羟乙氧基苯甲酸分别与已二酰氯、癸二酰氯和对苯二甲酰氯反应,制备了含酯键的二羧酸.经熔融缩聚,合成了主链含酯键的新型聚酯酸酐.通过1H NMR、IR及元素分析对单体及聚酯酸酐的结构进行了表征.研究了聚酯酸酐的体外降解和药物释放性能,其降解速率和释药速率次序为:聚4,4'-(已二酰氧二乙氧基)双对苯二甲酸＞聚4,4'-(癸二酰氧二乙氧基)双对苯二甲酸＞聚4,4'-(对苯二甲酰氧二乙氧基)双对苯二甲酸.
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| 关 键 词： | 聚酯酸酐 药物控制释放 环丙沙星 |
| 收稿时间： | 1996-12-23 |
Studies on the Syntheses and Properties of Poly(ester-anhydride)s for DDS |
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| FU Jie,ZHUO Ren-Xi,FAN Chang-Lie.Studies on the Syntheses and Properties of Poly(ester-anhydride)s for DDS[J].Chemical Research In Chinese Universities,1998,19(5):813-816. |
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| Authors: | FU Jie ZHUO Ren-Xi FAN Chang-Lie |
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| Institution: | Department of Chemistry, Laboratory of Biomedical Polymer Materials of the State Education Commission of China, Wuhan University, Wuhan, 430072 |
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| Abstract: | 4,4′-(Adipyldioxyethyoxy)dibenzoic acid(1a), 4,4′-(sebacoyldioxyethyoxy)dibenzoic acid(1b) and 4,4′-(benzoyldioxyethyoxy)dibenzoic acid(1c) were synthesized and converted into mixed anhydrides by the reaction with acetic anhydride. Poly(ester-anhydride)s 2a, 2b and 2c were yielded by subsequent melt polycondensation. Their chemical structures were confirmed by 1H NMR, IR, UV and elemental analysis. In vitro degradation of poly(ester-anhydride)s in phosphate buffer solution at 37 ℃ was determined. Drug release profile of Ciprofloxacin was also studied. |
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| Keywords: | Poly(ester anhydride) Drug controlled release Ciprofloxacin |
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