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Coriatone and corianlactone, two novel sesquiterpenes from Coriaria nepalensis
Authors:Shen Yun-Heng  Li Sheng-Hong  Li Rong-Tao  Han Quan-Bin  Zhao Qin-Shi  Liang Li  Sun Han-Dong  Lu Yang  Cao Peng  Zheng Qi-Tai
Affiliation:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P. R. China.
Abstract:Both coriatone (1). a novel highly oxygenated picrotoxane-type sesquiterpene, and corianlactone (2). with an unprecedented sesquiterpene basic skeleton, named coriane, were isolated from Coriaria nepalensis Wall. The structures of 1 and 2 were determined by analysis of their two-dimensional NMR data, and the structure of 2 was confirmed by X-ray analysis. Compounds 1 and 2 showed no remarkable inhibitory activity toward K(562) cells. They are cytotoxic with IC(50) > 50 microg/mL (cis-platinim: IC(50) = 0.49 microg/mL).
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