Application of ruthenium-induced macrocyclization for the construction of macrocyclic depsipeptides |
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| Authors: | Venkatraman Srikanth Njoroge F George Girijavallabhan Viyyoor McPhail Andrew T |
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| Institution: | Schering Plough Research Institute, K-15, 3545, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. Srikanth.Venkatraman@spcorp.com |
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| Abstract: | The synthesis of a biaryl ether containing macrocyclic depsipeptide 1 was achieved in 6% overall yield. The desired macrocycle was constructed by cyclization of a phenol into eta(6)-ruthenium complex. The ruthenium metal was subsequently photolytically deprotected to obtain the macrocycle 1. |
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