THE USE OF INTERNALIZABLE DERIVATIVES OF CHLORIN E6 FOR INCREASING ITS PHOTOSENSITIZING ACTIVITY |
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| Authors: | Tamara V Akhlynina Andrey A Rosenkranz David A Jans Pavel V Gulak Natalia V Sererryakova Alexander S Sobolev |
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| Institution: | Russian Research Center of Molecular Diagnostics and Therapy, Sympheropolsky Blvd. 8, 113149 Moscow, Russia;Max-Planck-Institut für Biophysik, Heinrich-Hoffmann-Str. 7, 6000 Frankfurt am Main 71, Germany |
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| Abstract: | Experiments with human hepatoma PLC/PRF/5 cells and human embryo skin fibroblasts involving the use of three different tests (colony formation, Trypan blue exclusion, labeled thymidine incorporation) have demonstrated a significantly higher photosensitizing activity of chlorin e6 conjugates with internalizable ligands as compared to that of chlorin e6 itself. Receptor-mediated internalization of chlorin e6 conjugates ensures a greater photosensitization of cells than binding of those conjugates to cell surface receptors. The suitability of such conjugates that permit the delivery of a photosensitizer to sensitive intracellular targets is discussed. |
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