Axonal outgrowth is associated with increased ERK 1/2 activation but decreased caspase 3 linked cell death in Schwann cells after immediate nerve repair in rats |
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| Authors: | Yoshifumi Tsuda Martin Kanje Lars B Dahlin |
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| Affiliation: | 1.Department of Orthopedic Surgery,National Defense Medical College,Saitama,Japan;2.Department of Cell and Organism Biology,Lund University,Lund,Sweden;3.Department of Clinical Sciences Malm? - Hand Surgery,Lund University,Malm? Sweden |
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| Abstract: | ![]()
Background Extracellular-signal regulated kinase (ERK1/2) is activated by nerve damage and its activation precedes survival and proliferation of Schwann cells. In contrast, activation of caspase 3, a cysteine protease, is considered as a marker for apoptosis in Schwann cells. In the present study, axonal outgrowth, activation of ERK1/2 by phosphorylation (p-ERK 1/2) and immunoreactivity of cleaved caspase 3 were examined after immediate, delayed, or no repair of transected rat sciatic nerves. |
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