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Controlled Release from and Tissue Response to Physically Bonded Hydrogel Nanoparticle Assembly |
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| Authors: | Zhibing Hu Xiaohu Xia Manuel Marquez Hong Weng Liping Tang |
| Affiliation: | 1. Departments of Physics and Chemistry, University of North Texas, P. O. Box 311427, Denton, Texas 76203, USA;2. Los Alamos National Laboratory, Chemistry Division, Los Alamos, New Mexico 87545, USA;3. Biomedical Engineering Program, University of Texas at Arlington, P.O. Box 19138, Arlington, Texas 76019, USA |
| Abstract: | Our recent work on synthesis and application of thermally gelling nanoparticle dispersions is briefly reviewed here. These nanoparticles consist of interpenetrating polymer networks (IPN) of poly-acrylic acid (PAAc) and poly(N-isopropylacrylamide) (PNIPAM). The aqueous IPN nanoparticle dispersions with polymer concentrations above 2.5 wt % underwent an inverse thermoreversible gelation at about 33 °C. Dextran markers of various molecular weights as model macromolecular pseudodrugs were mixed with the IPN nanoparticle dispersion at room temperature. At body temperature, the dispersion became a gel. The dextran release profiles were then measured using UV-visible spectroscopy. The biocompatibility of this nanoparticle assembly was assessed using an animal implantation model. |
| Keywords: | biocompatibility drug delivery systems gelation hydrogels nanoparticles |