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Direct access to 2-debenzoyl taxoids by electrochemistry, synthesis of 2-modified docetaxel analogs |
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| Authors: | Jean-Pierre Pulicani, Daniel B zard, Jean-Dominique Bourzat, Herv Bouchard, Martine Zucco, Dominique Deprez,Alain Commer on |
| Affiliation: | Rhône-Poulenc Rorer S.A.-Centre de Recherches de Vitry-Alfortville 13, Quai Jules Guesde - BP14 - 94403 Vitry-sur-Seine France |
| Abstract: | A new route to semisynthetic 2-modified docetaxel analogs is described using electrochemical cleavage of the 2-benzoate as the key reaction. Subsequent reacylation at C-2 followed by sequential deprotections afforded the title analogs. Biological results of selected 2-docetaxel analogs are presented. |
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