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Efficient synthesis of phosphorus-containing dendrimers capped with isosteric functions of amino-bismethylene phosphonic acids
Authors:Olivier Rolland,Cé  dric-Olivier Turrin,Gé  rard Bacquet,Mary Poupot,Jean-Pierre Majoral
Affiliation:a CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, F-31077 Toulouse, France
b Université de Toulouse, UPS, INPT, LCC, F-31077 Toulouse, France
c Rhodia, Centre de Recherches d’Aubervilliers 52 rue de la Haie Coq, F-93308 Aubervilliers Cedex, France
d INSERM 563, Centre de Physiopathologie de Toulouse-Purpan, Hôpital Purpan, BP 3048, F-31024, Toulouse Cedex 03, France
Abstract:An efficient synthetic strategy to synthesize phosphorus-containing dendrimers capped with isosteric acid functions derived from tyramine is described. The method is demonstrated on a first generation dendrimer that can be easily capped with 12 amino(bismethylene) sulfonic acids and amino(bismethylene) carboxylic acids that are strict analogs of the corresponding amino(bismethylene) phosphonic acids.
Keywords:Dendrimers   Phosphonate   Sulfonate   Carboxylate   Polyanions
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