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A simple O-sulfated thiohydroximate molecule to be the first micromolar range myrosinase inhibitor |
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| Authors: | Deimante Cerniauskaite Estelle Gallienne Andrea SF Farinha Sylvie Armand Algirdas Sackus |
| Institution: | a Institut de Chimie Organique et Analytique, Associé au CNRS, Université d’Orléans, B.P. 6759, F-45067 Orléans, France b Kaunas University of Technology, Radvilenu st.19, LT-50270 Kaunas, Lithuania c Centre de Recherche sur les Macromolécules Végétales (CERMAV-CNRS), Affiliated with Université Joseph Fourier, Grenoble, BP 53, F-38041 Grenoble Cedex 9, France |
| Abstract: | New non-hydrolyzable analogues of glucosinolates have been prepared. Myrosinase inhibition was observed with modified aglycon moieties, even bulky phenothiazine analogue 6 gave reasonable inhibition. The simplest structure 8 derived from dimethylaminoethanethiol has shown to be the most potent inhibitor with an IC50 of 3.32 μM. |
| Keywords: | Glucosinolate Myrosinase inhibition Thiohydroximate Sulfation |
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