Efficient syntheses of enantioenriched (R)-pipecolic acid and (R)-proline via electrophilic organocatalytic amination |
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| Authors: | Delphine Kalch |
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| Affiliation: | Institut Lavoisier de Versailles, UMR CNRS 8180, Université de Versailles St-Quentin-en-Yvelines, 45, Avenue des Etats-Unis, 78035 Versailles Cedex, France |
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| Abstract: | ![]()
Five-step syntheses of (R)-pipecolic acid and (R)-proline are described, respectively, from cyclohexene and cyclopentene. The key step involves the organocatalytic α-amination of functionalized aldehydes. |
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| Keywords: | Amination Organocatalysis Enantioselectivity Cyclic aminoacid |
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