An efficient Friedel-Crafts alkylation of nitrogen heterocycles catalyzed by antimony trichloride/montmorillonite K-10 |
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| Authors: | Yu-Heng Liu |
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| Institution: | The College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang, PR China |
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| Abstract: | It has been found that SbCl3 supported on montmorillonite K-10 is an efficient and reusable catalyst for Friedel-Crafts alkylation of nitrogen heterocycles such as indoles and pyrroles with epoxides. The reaction gives the corresponding C-alkylated derivatives in good to excellent yields with a high regioselectivity. |
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| Keywords: | Epoxides Ring opening Friedel-Crafts alkylation Nitrogen heterocycle Indole Pyrrole Antimony trichloride Montmorillonite K-10 |
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