Efficient conversion of thymine glycol into the formamide lesion in oligonucleotides |
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| Authors: | Tatsuya Toga |
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| Affiliation: | Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan |
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| Abstract: | Oxidation of (5R,6S)-5,6-dihydro-5,6-dihydroxythymidine (thymidine glycol) with sodium periodate efficiently produced N-(2-deoxy-β-d-erythro-pentofuranosyl)formamide, a hydroxyl radical-induced decomposition product of pyrimidine bases in DNA, and this method was successfully applied to the conversion of thymine glycol in oligonucleotides into the formamide lesion. |
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| Keywords: | Oligonucleotides DNA damage Thymine glycol Periodate oxidation |
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