A new synthesis of 2-(hetero)aryl-substituted pyrazines |
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| Authors: | Arumugam Kodimuthali B Chandra Chary Manojit Pal |
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| Institution: | a New Drug Discovery, R&D Center, Matrix Laboratories Ltd., Anrich Industrial Estate, Bollaram, Jinnaram Mandal, Medak District, Andra Pradesh 502 325, India
b Department of Chemistry, University College of Science, Osmania University, Hyderabad 500 007, India |
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| Abstract: | 2-Chloropyrazine showed remarkable reactivity towards AlCl3-mediated heteroarylation of arenes and heteroarenes providing direct access to a variety of 2-aryl and heteroaryl-substituted pyrazines, respectively, in good to excellent yields under mild reaction conditions. |
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