Synthesis and PKC binding of a new class of a-ring diversifiable bryostatin analogues utilizing a double asymmetric hydrogenation and cross-coupling strategy |
| |
Authors: | Wender Paul A Horan Joshua C |
| |
Institution: | Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. wenderp@stanford.edu |
| |
Abstract: | The design, asymmetric synthesis, and biological evaluation of a new class of bryostatin analogues based on a pseudosymmetric spacer domain are described. An aryl bromide diversification site is incorporated allowing access to systematically varied analogues. The new analogues all exhibit potent, nanomolar affinity to PKC. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|