Practical synthesis and elaboration of methyl 7-chloroindole-4-carboxylate |
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| Authors: | Alper Phil B Nguyen KhanhLinh T |
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| Institution: | The Genomics Institute of the Novartis Foundation, 10675 John Jay Hopkins, San Diego, California 92121-1125, USA. palper@gnf.org |
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| Abstract: | A synthesis of a previously unknown indole derivative is presented. The route reported herein allows for the preparation of multihundred gram quantities of material without any chromatographic purification. Conditions are presented for the Pd-catalyzed elaboration of one of the "diversity generating elements" of this important pharmacophore. |
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