Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp isolated from Cinchona pubescens |
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| Authors: | Shibuya Hirotaka Kitamura Chinami Maehara Shoji Nagahata Marie Winarno Hendig Simanjuntak Partomuan Kim Hye-Sook Wataya Yusuke Ohashi Kazuyoshi |
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| Institution: | Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan. shibuya@fupharm.fukuyama-u.ac.jp |
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| Abstract: | The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives. |
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