Synthesis of novel,azasugar-modified anthraquinone derivatives and their cytotoxicity |
| |
| Authors: | Ping-Zhu Zhang ;Hai-Long Yang ;Cui-Cui Li ;Zhi-Chao Xia ;Xiao-Man Wang ;Hua Wei ;Rui-Xue Rong ;Zhi-Ran Cao ;Ke-Rang Wang ;Hua Chen ;Xiao-Liu Li |
| |
| Institution: | a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China;
b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, China;
c Department of Immunology, School of Basic Medical Science, Hebei University, Baoding 071002, China |
| |
| Abstract: | A series of novel, azasugar-modified 2-monosubstituted, 2,6- and 2,7-bissubstituted anthraquinone derivatives have been synthesized by the nucleophilic substitution of N-alkylamino azasugar with mono-, bis(2-chloroacetamido)anthraquinones. Their cytotoxic activities against HeLa and MCF-7 cells were preliminarily evaluated and compound 9a with mono-azasugar pendant at 2-position showed similar activity to the control drug(Cisplatin). |
| |
| Keywords: | Anthraquinone Azasugar Cytotoxic activity |
| 本文献已被 CNKI 维普 ScienceDirect 等数据库收录！ |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
| 点击此处可从《中国化学快报》下载免费的PDF全文 |
|
