| Lipase-catalyzed Knoevenagel condensation between α,β-unsaturated aldehydes and active methylene compounds |
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| 作者姓名： | Zhi Wang ;Chun-Yu Wang ;Hao-Ran Wang ;Hong Zhang ;Ya-Lun Su ;Teng-Fei Ji ;Lei Wang |
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| 作者单位： | a Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130023, China;
b State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
c State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130023, China |
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| 基金项目： | the financial support from the National Natural Science Foundation of China （Nos. 21172093, 31070708, and 21072075）; the Natural Science Foundation of Jilin Province of China （Nos. 201115039 and 20140101141JC）; the Scientific Research Fund of Jilin University （No. 450060326007） |
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| 摘 要： | A simple and efficient Knoevenagel condensation between a b-unsaturated aldehydes and active methylene compounds is reported.Notably,this condensation can be catalyzed by PPL(lipase from porcine pancreas) with satisfied yields(49%–92%).Moreover,PPL induces moderate Z/E selectivity in the Knoevenagel condensation.
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| 关 键 词： | Knoevenagel缩合反应 活性亚甲基化合物 不饱和醛 脂肪酶 酶催化 收益率 PPL |
| 收稿时间： | 15 January 2014 |
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