Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue |
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| Authors: | Nakanishi Ikuo Nishizawa Chiho Ohkubo Kei Takeshita Keizo Suzuki Kazuo T Ozawa Toshihiko Hecht Sidney M Tanno Masayuki Sueyoshi Shoko Miyata Naoki Okuda Haruhiro Fukuzumi Shunichi Ikota Nobuo Fukuhara Kiyoshi |
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| Institution: | Redox Regulation Research Group, Research Center for Radiation Safety, National Institute of Radiological Sciences (NIRS), Inage-ku, Chiba, 263-8555, Japan. nakanis@nirs.go.jp |
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| Abstract: | Photoreduction of pyridine N-oxide, which has a key structure of antitumor agents for hypoxic solid tumors, by 1-benzyl-1,4-dihydronicotinamide in deaerated aprotic media resulted in generation of hydroxyl radical, leading to the oxidation of salicylic acid to 2,3- and 2,5-dihydroxybenzoic acids, and catechol. |
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