Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of Plant Pathogenic Fungi |
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Authors: | Koonchira Buaban Weerachai Phutdhawong Thongchai Taechowisan Waya S Phutdhawong |
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Institution: | 1.Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand;2.Department of Science, Faculty of Liberal Arts and Science, Kamphaeng Sean Campus, Kasetsart University, Nakhon Pathom 73140, Thailand;3.Department of Microbiology, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand; |
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Abstract: | A series of tetrahydro-ß-carbolines substituted with an alkyl or acyl side chain was synthesized and screened for its antifungal activity against plant pathogenic fungi (Bipolaris oryzae, Curvularia lunata, Fusarium semitectum, and Fusarium fujikuroi). The structure activity relationship revealed that the substituent at the piperidine nitrogen plays an important role for increasing antifungal activities. In this series, 2-octyl-2,3,4,9-tetrahydro-1H-pyrido3,4-b]indole (3g) displayed potent antifungal activities with a minimum inhibitory concentration of 0.1 μg/mL, including good inhibitory activity to the radial growth of fungus at a concentration of 100 μg/mL compared to amphotericin B. |
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Keywords: | tetrahydro-β -carbolines (THβ Cs) plant pathogenic fungi radial growth N-substituted THβ Cs |
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