Bismuth-Catalyzed Amide Reduction |
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| Authors: | Dr Xiuxiu Yang Jennifer Kuziola Dr Vanessa A Béland Julia Busch Dr Markus Leutzsch Dr Jordi Burés Dr Josep Cornella |
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| Institution: | 1. Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany;2. University of Manchester, Oxford Road, M13 9PL Manchester, UK |
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| Abstract: | In this article we report that a cationic version of Akiba's BiIII complex catalyzes the reduction of amides to amines using silane as hydride donor. The catalytic system features low catalyst loadings and mild conditions, en route to secondary and tertiary aryl- and alkylamines. The system tolerates functional groups such as alkene, ester, nitrile, furan and thiophene. Kinetic studies on the reaction mechanism result in the identification of a reaction network with an important product inhibition that is in agreement with the experimental reaction profiles. |
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| Keywords: | Amides Bismuth Kinetics Reaction Mechanisms Reduction |
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