Fluorous ligand capture (FLC): a chemoselective solution-phase strategy for isolating 99mTc-labelled compounds in high effective specific activity |
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| Authors: | Hicks Justin W Harrington Laura E Valliant John F |
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| Affiliation: | Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada. |
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| Abstract: | ![]()
A new approach for preparing (99m)Tc-labelled compounds in high effective specific activity was developed by utilizing a novel fluorous ligand capture (FLC) agent and a chemoselective filtration strategy. This paradigm eliminates the need to use HPLC to obtain technetium(I) based molecular imaging probes free from residual precursor. |
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