| 金鸡纳生物碱电喷雾质谱裂解规律研究 |
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| 引用本文： | 韩凤梅,陈琳,陈勇.金鸡纳生物碱电喷雾质谱裂解规律研究[J].分析科学学报,2005,21(4):390-392. |
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| 作者姓名： | 韩凤梅 陈琳 陈勇 |
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| 作者单位： | 湖北大学生命科学学院中药生物技术实验室,武汉,430062 |
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| 基金项目： | 湖北省杰出青年科学基金 |
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| 摘 要： | 利用电喷雾离子阱质谱（ES-ITMS）技术进行了金鸡纳中4种喹啉类生物碱（奎宁、奎尼定、辛可宁和辛可尼定）的电喷雾质谱研究。在优化的质谱条件下，正离子全扫描时，4种生物碱都易形成带一个质子的分子离子；进一步碰撞诱导解离四种母离子，二级质谱表明羟基丢失、奎宁环断裂及重排为其主要裂解方式。
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| 关 键 词： | 奎宁 奎尼定 辛可宁 辛可尼定 电喷雾离子阱质谱 裂解规律 |
| 文章编号： | 1006-6144(2005)04-0390-03 |
| 收稿时间： | 2004-04-28 |
| 修稿时间： | 2004年4月28日 |
Study on the Dissociation Laws of Four Alkaloids in Cinchona by Electrospray Ionization MS |
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| HAN Feng-mei,CHEN Lin,CHEN Yong.Study on the Dissociation Laws of Four Alkaloids in Cinchona by Electrospray Ionization MS[J].Journal of Analytical Science,2005,21(4):390-392. |
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| Authors: | HAN Feng-mei CHEN Lin CHEN Yong |
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| Abstract: | The MS behaviors and dissociation laws of four alkaloids in Cinchona were studied by direct infusion into electrospray ion trap mass spectrometry (ESI-ITMS). The analytes (dissolved in methanol) easily formed molecular ions (\~(+)) in positive detection mode. In CID detection mode,the simple substituents such as -OH were easy to loss in the four alkaloids, and the dissociation and rearrangement of quinuclidine were also the primary behaviors of those analytes. |
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| Keywords: | Quinine Quinidine Cinchonine Cinchonidine ESI-ITMS Dissociation law |
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