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NMR studies of inclusion complexation of the pyrrolizidine alkaloid retronecine and p-sulfonic acid calix[6]arene |
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| Authors: | Daniel Leite da Silva Eder do Couto Tavares Leila de Souza Conegero ?ngelo de F??tima Ronaldo Aloise Pilli Sergio Antonio Fernandes |
| Institution: | 1. Grupo de Qu??mica Supramolecular e Biomim??tica (GQSB), Departamento de Qu??mica, Universidade Federal de Vi?osa (UFV), Campus Universit??rio, Avenida P.H. Rolfs, s/n, Vi?osa, MG, 36570-000, Brazil 3. Grupo de Estudos em Qu??mica Organica e Biol??gica (GEQOB), Departamento de Qu??mica, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Pampulha, MG, 31270-901, Brazil 2. Departamento de Qu??mica Organica, Instituto de Qu??mica, Universidade Estadual de Campinas (UNICAMP), CP 6154, Campinas, SP, 13084-971, Brazil |
| Abstract: | Accidental or intentional drug toxicity in humans and animals is a major concern and the search for detoxificant agents is a challenge. Pyrrolizidine-producing forages are a threat not only to livestock, but also to humans as a consequence of food contamination. Supramolecular systems are promising as detoxificant agents by decreasing the bioavailability of toxic compounds in biological environment. Cyclodextrin and calixn]arenes are well known hosts for a variety of molecules and/or ions. Surprisingly, only few studies describe the potential of calixn]arenes as host for toxic molecules. This study focused on the use of NMR techniques as tools for the investigation of the interactions between p-sulfonic acid calix6]arene and retronecine, a toxic pyrrolizidine alkaloid. |
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