吴茱萸次碱的合成进展

系统地总结了吴茱萸次碱的合成方法. 根据构建环的种类不同, 把合成方法分为七类, 大部分方法都是以色胺和邻氨基苯甲酸或其衍生物为起始原料, 步骤较长, 适合工业生产的简便、经济适用的方法还有待于进一步研究探索.

Progress in the Synthesis of Rutaecarpine

Rutaecarpine belongs to the quinazolinocarboline type of alkaloids isolated from the fruits of Evodia rutaecarpa, which has been used in traditional Chinese medicine under the name Wu-Zhu-Yu against e.g. headache, dysentery, cholera, worm infections and postpartum disturbances. In literature, rutae-carpine and its derivatives have been reported to have cycloxygenase (COX-2) inhibitory, hypotensive, an-tiarrhythmic, antiplatelet aggregation, vasorelaxation and anti-anoxic activities. Owing to its pharmaceutical activities, attention is still focused on the development of new synthetic methods for rutaecarpine. Several methods of synthesis of rutaecarpine are reviewed according to the types of building chemical structures. Rutaecarpine was mostly made by tryptamine and anthranilic acid or their derivaties through complicated steps. So, the simple and convenient methods are still needed.