Continuous-wave stimulated Raman scattering (cwSRS) microscopy |
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Authors: | Zhaokai Meng Georgi I Petrov Vladislav V Yakovlev |
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Institution: | 1. Department of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA
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Abstract: | Stimulated Raman scattering (SRS) microscopy is a powerful tool for chemically sensitive non-invasive optical imaging. However, ultrafast laser sources, which are currently employed, are still expensive and require substantial maintenance to provide temporal overlap and spectral tuning. SRS imaging, which utilizes continuous-wave laser sources, has a major advantage, as it eliminates the cell damage due to exposure to the high-intensity light radiation, while substantially reducing the cost and complexity of the setup. As a proof-of-principle, we demonstrate microscopic imaging of dimethyl sulfoxide using two independent, commonly used lasers, a diode-pumped, intracavity doubled 532-nm laser and a He–Ne laser operating at 632.8-nm. |
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