| 天然产物5,7-二甲氧基-4′-羟基异黄酮的合成 |
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| 引用本文： | 任宛莉,陈东玲,金叶,李洪启.天然产物5,7-二甲氧基-4′-羟基异黄酮的合成[J].化学研究,2009,20(4):10-13. |
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| 作者姓名： | 任宛莉 陈东玲 金叶 李洪启 |
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| 作者单位： | 1. 宝鸡职业技术学院医学部,陕西,宝鸡,721006
2. 东华大学化学化工与生物工程学院,生态纺织教育部重点实验室,上海,201620 |
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| 基金项目： | 教育部留学回国人员科研启动基金，上海市自然科学基金项目 |
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| 摘 要： | 以4-羟基苯乙酸和3,5-二甲氧基苯酚为原料,通过一条包括苄基化、酰氯化、酯化、氢化、Fries重排、以及Vilsmeier-Haack反应等6步反应的路线合成了天然产物5,7-二甲氧基-4′-羟基异黄酮,目标产物的总收率为33%.利用1HNMR、13C NMR及元素分析确证了化合物的结构.
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| 关 键 词： | 5 7-二甲氧基-4′-羟基异黄酮 4-羟基苯乙酸 3 5-二甲氧基苯酚 Fries重排 Vilsmeier-Haack反应 |
Synthesis of Natural Product 5,7-Dimethoxyl-4'-Hydroxyisoflavone |
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| REN Wan-li,CHEN Dong-ling,JIN Ye,LI Hong-qi.Synthesis of Natural Product 5,7-Dimethoxyl-4'-Hydroxyisoflavone[J].Chemical Research,2009,20(4):10-13. |
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| Authors: | REN Wan-li CHEN Dong-ling JIN Ye LI Hong-qi |
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| Institution: | REN Wan-li, CHEN Dong-ling, JIN Ye, LI Hong-qi ( 1. Medical School, Baoji Vocational and Technological College, Baoji 721006, Shaanxi, China; 2, Key Laboratory of Science ＆ Technology of Eco-Textile, Ministry of Education, College of Chemistry Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China) |
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| Abstract: | The natural product 5,7-dimethoxyl-4′-hydroxyisoflavone was synthesized by using a 6-step synthetic protocol including benzylization,acyl chloride forming reaction,esterification,hydrogenation,Fries transformation and Vilsmeier-Haack reaction with 4-hydroxyphenylacetic acid and 3,5-dimethoxyphenol as the starting materials.The overall yield of the target compound was 33%.The structures of the target compounds were confirmed by 1H NMR,13C NMR and elemental analysis. |
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| Keywords: | 5 7-dimethoxyl-4′-hydroxyisoflavone 4-hydroxyphenylacetic acid 3 5-dimethoxyphenol Fries transformation Vilsmeier-Haack reaction |
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