Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus |
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| Authors: | Brady S F Singh M P Janso J E Clardy J |
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| Institution: | Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA. |
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| Abstract: | structure] The biochemical induction assay (BIA) is a rapid (colorimetric) bacterial assay used to identify compounds that damage DNA or inhibit DNA synthesis and thereby identify potential natural product anticancer agents. Bisanthraquinones based on a 1,3,6, 8-tetrahydroxyanthraquinone-type carbon skeleton were isolated from an endophytic fungus and characterized by NMR and X-ray crystallography. Cytoskyrin A (1) is highly active in the biochemical induction assay, while the closely related cytoskyrin B (2) has no detectable activity in this assay. |
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