| Abstract: | Phtalazines and 4(3H)-phthalazones are aminoalkylated in high yield by 3-dimethylaminopropyl-magnesiumchloride. Phthalazines add only one molecule of the GRIGNARD reagent at the C?N-double bond, giving mono-aminoalkylated 1,2-dihydrophthalazines which undergo no further reaction without previous oxydation. Phthalazones react with the carbonyl and the C?N-group yielding in one step di-aminoalkylated dihydrophthalazines. The dihydrophthalazines are easily oxydized with K3Fe(CN)6 to the corresponding phthalazines. |
