Spectroscopic evidence for the unusual stereochemical configuration of an endosome-specific lipid |
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Authors: | Tan Hui-Hui Makino Asami Sudesh Kumar Greimel Peter Kobayashi Toshihide |
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Institution: | Lipid Biology Laboratory, ASI RIKEN, 351-0198, Japan. |
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Abstract: | At a glance: The stereochemical configuration of the diglycerophosphate backbone of the endosome-specific lipid bis(monoacylglycero)phosphate (BMP, see picture) was determined by (1)H?NMR spectroscopy. Enantiomeric discrimination was facilitated by introduction of D-camphor ketals as chiral shift reagents, and enantiopure synthetic BMP analogues were prepared as reference materials. Natural BMP exhibited the unusual sn-1,1' diglycerophosphate backbone. |
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Keywords: | configuration determination NMR spectroscopy phospholipids structure elucidation |
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