Towards the synthesis of sulfonamide-based RNA mimetics |
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| Authors: | Jeroen van Ameijde Thierry K. Slot Rob M.J. Liskamp |
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| Affiliation: | Medicinal Chemistry and Chemical Biology, Faculty of Science, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands |
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| Abstract: | ![]()
The scalable, divergent synthesis of all four monomers required for the preparation of sulfonamide-based RNA mimetics is described. Such mimetics may combine excellent mimicry of the parent RNA with enhanced (bio)chemical robustness and convenient oligomerization. As a proof of principle, a dimer resulting from the monomers is described. |
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