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Kinetic resolution of iodophenylethanols by Candida antarctica lipase and their application for the synthesis of chiral biphenyl compounds |
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| Authors: | Lenilson C Rocha Isac G Rosset Rodrigo F Luiz Cristiano Raminelli André LM Porto |
| Institution: | 1. Instituto de Química de São Carlos, Universidade de São Paulo, Av. Trabalhador São-carlense, 400, CEP 13560-970, São Carlos, SP, Brazil;2. Faculdade de Ciências Exatas e Tecnologia, Universidade Federal da Grande Dourados, Rodovia Dourados-Itahum, Km 12, CEP 79804-970, Dourados, MS, Brazil |
| Abstract: | The kinetic resolution of (±)-iodophenylethanols was carried out using lipase from Candida antarctica and in some cases the enantiomeric excesses were high (up to >98%). Enantiomerically enriched (S)-iodophenylethanols produced by the enzymatic resolution process were used in the synthesis of chiral biphenyl compounds by the Suzuki reaction with good yields (63–65%). |
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