Resolution approaches to enantiomers of 4-formyl[2.2]paracyclophane |
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| Authors: | Elena V Sergeeva Ivan A Shuklov Dmitrii Yu Antonov Natalia V Vorontsova Evgenii V Vorontsov Zoya A Starikova Michail M Il’in Valeria I Rozenberg |
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| Institution: | 1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Science, Vavilova str. 28, 119991 Moscow, Russian Federation;2. Leibniz-Institut für Katalyse e.V. an der Universität Rostock (LIKAT) Albert-Einstein-Str. 29a, 18059 Rostock, Germany |
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| Abstract: | Three techniques for the resolution of 4-formyl2.2]paracyclophane were examined with the separation of the diastereomeric derivatives with (R)- and (S)-2-hydrazino-2-oxo-N-(1-phenylethyl)acetamide followed by their hydrolysis being found to be the most efficient, allowing (Rp)- and (Sp)-4-formyl2.2]paracyclophanes to be obtained with 99.5% and 98.7% ee, respectively. |
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