Chiral phosphinothiourea-catalyzed asymmetric Morita-Baylis-Hillman reactions of acrylates with aromatic aldehydes |
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| Authors: | Kui Yuan |
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| Affiliation: | Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | ![]()
A series of chiral bifunctional phosphinothioureas were synthesized and applied to the enantioselective Morita-Baylis-Hillman reaction of aromatic aldehydes with acrylates. In the presence of 8 mol % of organocatalyst 2e, the Baylis-Hillman adducts were obtained in good enantioselectivities and up to 96% yield under mild reaction conditions. |
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| Keywords: | Chiral phosphinothiourea Acrylate Asymmetric organocatalysis Enantioselective Morita-Baylis-Hillman reaction |
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