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Metal–Nitrosyl complexes as a source of new vasodilators: Strategies derived from systematic chemistry and nitrosyl ligand reactivity
Authors:J. Reglinski  A. R. Butler  C. Glidewell
Abstract:A series of nitrosyl complexes of empirical formula Kn[M(CN)5NO], where M = V, Cr, Mn and Co and n = 3, or M = Mo and n = 4, have been prepared which are notional analogues of the widely used vasodilator sodium nitroprusside. Their reactivity towards common nucleophiles (OH?, NH2R, NHR2, HS? and RS?), acid and photolysis has been investigated to elucidate the desired properties required of new metal nitrosyls which may have some potential as new non-cyanide-based vasodilators.
Keywords:Nitric oxide complexes  vasodilators  nitrosyls  nitroprusside analogues
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